Department: Lewis-Sigler Institute for Integrative Genomics
Faculty Adviser: Yuri Pritykin
Year of Study: G2
Undergraduate School: Vanderbilt University
Undergraduate Major: Molecular&Cellular Biology
Hey! I'm Amanda, and I'm a grad student in the Quantitative and Computational Biology program. I grew up in Missouri and went to undergrad at Vanderbilt University in Nashville, TN. There, I studied biology and computer science, and I did research studying DNA replication-transcription conflicts in Drosophila (though that's pretty different from what I do now!). From living in Nashville, I also picked up a habit of saying y'all and great appreciation for brunch and spicy fried chicken.
I think pineapple on pizza is great and mint ice cream tastes like toothpaste, but this is open for discussion.
In general, I'm interested in using computational methods for biological questions related to human health and disease. My research looks at how the immune system functions, particularly in relationship to cancer. I'm also studying the effects of anti-PD-1 treatment, a cancer treatment that targets immune cells, to better understand how this immunotherapy works and how treatments can be improved. To answer these questions, I'm using gene expression data, including single-cell RNA sequencing and spatially resolved transcriptomics. By looking at the gene expression (and the changes in gene expression) in tumor and immune cells, I can analyze the characteristics of different cell types to understand how they function and interact both during cancer generally and after immunotherapy treatment. With this data, I'm using existing tools for RNA sequencing analysis as well as developing my own methods based on statistical and computational analysis.
Plans for Summer 2022
Not available to participate in Summer ReMatch+ program.